Reduced expression of PBP-2A by neonatal mecA-positive coagulase-negative staphylococci (CoNS) blood isolates: -lactams are useful first-line agents for the treatment of neonatal CoNS sepsis, restricting the use of vancomycin | Zendy

A. Fleer | Zendy; Marieke A. C. Hemels | Zendy; Armand Paauw | Zendy; Tannette G. Krediet | Zendy

Open Access

Reduced expression of PBP-2A by neonatal mecA-positive coagulase-negative staphylococci (CoNS) blood isolates: -lactams are useful first-line agents for the treatment of neonatal CoNS sepsis, restricting the use of vancomycin

Author(s) -

A. Fleer,

Marieke A. C. Hemels,

Armand Paauw,

Tannette G. Krediet

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks092

Subject(s) - cons , microbiology and biotechnology , coagulase , penicillin binding proteins , sccmec , neonatal sepsis , penicillin , antibiotics , biology , carriage , cefazolin , sepsis , staphylococcus , medicine , staphylococcus aureus , bacteria , methicillin resistant staphylococcus aureus , immunology , genetics , pathology , computer science , programming language

Vancomycin use for neonatal coagulase-negative staphylococci (CoNS) sepsis is based on a high CoNS carriage rate of mecA, encoding penicillin-binding protein (PBP)-2a, with low affinity for, and associated with resistance to, β-lactam antibiotics. The relationship between mecA gene carriage, phenotypic expression of the gene by PBP-2a production and in vitro resistance to the β-lactam antibiotics oxacillin, cefazolin and amoxicillin/clavulanate was determined for 85 CoNS blood isolates randomly obtained from our collection of isolates from neonates with CoNS sepsis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research