Diabetic murine models for Acinetobacter baumannii infection | Zendy

Guopei Luo | Zendy; Brad Spellberg | Zendy; Teclegiorgis Gebremariam | Zendy; Michael Bolaris | Zendy; Hochul Lee | Zendy; Yue Fu | Zendy; Samuel W. French | Zendy; Ashraf S. Ibrahim | Zendy

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Diabetic murine models for Acinetobacter baumannii infection

Author(s) -

Guopei Luo,

Brad Spellberg,

Teclegiorgis Gebremariam,

Michael Bolaris,

Hochul Lee,

Yue Fu,

Samuel W. French,

Ashraf S. Ibrahim

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks050

Subject(s) - acinetobacter baumannii , tigecycline , colistin , pneumonia , medicine , antibiotics , diabetes mellitus , microbiology and biotechnology , intensive care medicine , biology , pseudomonas aeruginosa , bacteria , genetics , endocrinology

Extremely drug-resistant (XDR; i.e. resistant to all antibiotics except colistin or tigecycline) Acinetobacter baumannii has emerged as one of the most common and highly antibiotic-resistant causes of infection. Diabetes is a risk factor for acquisition of and worse outcomes from A. baumannii infection. We sought to develop diabetic mouse models of A. baumannii bacteraemia and pneumonia and validate these models by comparing the efficacy of antibiotic treatment in these models with the established neutropenic mouse models.

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