Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz | Zendy

W. Kromdijk | Zendy; Jan W. Mulder | Zendy; Hilde Rosing | Zendy; Patrick M. Smit | Zendy; Jos H. Beijnen | Zendy; Alwin D. R. Huitema | Zendy

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Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz

Author(s) -

W. Kromdijk,

Jan W. Mulder,

Hilde Rosing,

Patrick M. Smit,

Jos H. Beijnen,

Alwin D. R. Huitema

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks011

Subject(s) - efavirenz , nevirapine , dried blood spot , dried blood , therapeutic drug monitoring , blood sampling , blood plasma , pharmacokinetics , medicine , spots , pharmacology , sampling (signal processing) , human immunodeficiency virus (hiv) , virology , chemistry , chromatography , antiretroviral therapy , viral load , pathology , computer science , filter (signal processing) , computer vision

Plasma concentrations are frequently used for therapeutic drug monitoring of antiretroviral drugs. Dried blood spot sampling offers a patient-friendly and easy alternative to plasma sampling. However, dried blood spot concentrations are not necessarily equal to plasma concentrations and therefore the objective of this work was to establish the relationship between nevirapine and efavirenz dried blood spot and plasma concentrations to facilitate clinical implementation of dried blood spot sampling.

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