Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model | Zendy

L. Christensen | Zendy; Maria van Gennip | Zendy; Tim Holm Jakobsen | Zendy; Morten Alhede | Zendy; H P Hougen | Zendy; Niels Høiby | Zendy; Thomas Bjarnsholt | Zendy; Michael Givskov | Zendy

Open Access

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

Author(s) -

L. Christensen,

Maria van Gennip,

Tim Holm Jakobsen,

Morten Alhede,

H P Hougen,

Niels Høiby,

Thomas Bjarnsholt,

Michael Givskov

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks002

Subject(s) - pseudomonas aeruginosa , tobramycin , quorum sensing , biofilm , microbiology and biotechnology , in vivo , in vitro , antibiotics , chemistry , biology , bacteria , gentamicin , biochemistry , genetics

Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.

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