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The mechanism explaining the strong association between IL28B rs12979860 polymorphisms and treatment outcome in chronic hepatitis C remains unclear. We explore whether IL28B protein [interferon (IFN)-λ3] plasma levels may vary according to IL28B genotype and/or following pegylated IFN-α/ribavirin therapy.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Impact of IL28B gene polymorphisms on interferon- 3 plasma levels during pegylated interferon- /ribavirin therapy for chronic hepatitis C in patients coinfected with HIV