Co-amoxiclav induces proliferation and cytotoxin production of Clostridium difficile ribotype 027 in a human gut model
Author(s) -
C. H. Chilton,
Jane Freeman,
G. S. Crowther,
S. L. Todhunter,
Scott Nicholson,
M. H. Wilcox
Publication year - 2012
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr584
Subject(s) - clostridium difficile , microbiology and biotechnology , antibiotics , clostridiaceae , clostridium , biology , medicine , bacteria , toxin , genetics
Co-amoxiclav is widely prescribed in hospitals. Although reports have suggested it may be linked to onset of Clostridium difficile infection (CDI), data on the risk of CDI associated with specific antibiotics is difficult to obtain, due to confounding clinical factors. We have examined the propensity of co-amoxiclav to induce CDI using a human gut model.
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