Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor | Zendy

Tristan Barber | Zendy; Linda Harrison | Zendy; David Asboe | Zendy; Ian Williams | Zendy; Stuart A. Kirk | Zendy; Richard Gilson | Zendy; Clifford Leen | Zendy; Deenan Pillay | Zendy; David Dunn | Zendy

Open Access

Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor

Author(s) -

Tristan Barber,

Linda Harrison,

David Asboe,

Ian Williams,

Stuart A. Kirk,

Richard Gilson,

Clifford Leen,

Deenan Pillay,

David Dunn

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr569

Subject(s) - lopinavir , ritonavir , protease inhibitor (pharmacology) , protease , virology , mutation , medicine , gene , biology , human immunodeficiency virus (hiv) , genetics , viral load , antiretroviral therapy , enzyme , biochemistry

Selection of protease mutations on antiretroviral therapy (ART) including a ritonavir-boosted protease inhibitor (PI) has been reported infrequently. Scarce data exist from long-term cohorts on resistance incidence or mutational patterns emerging to different PIs.

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