Antibiotic prophylaxis for cardiac surgery
Author(s) -
Ron Kappeler,
M. Gillham,
Nicholas M. Brown
Publication year - 2011
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr536
Subject(s) - medicine , antibiotic prophylaxis , pneumonia , randomized controlled trial , antibiotics , cardiac surgery , regimen , intensive care medicine , surgery , meta analysis , microbiology and biotechnology , biology
Antibiotic prophylaxis for cardiac surgery is a controversial area. Recent systematic reviews and meta-analyses of randomized controlled trials have concluded that surgical site infection can be reduced by prolonging prophylaxis for 24-48 h. Also, post-operative pneumonia and all-cause mortality can be reduced by giving agents with both anti-Gram-negative and anti-Gram-positive activity. The choice of the most appropriate regimen remains open to debate.
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