Inter- and intra-patient variability of raltegravir pharmacokinetics in HIV-1-infected subjects | Zendy

Dario Cattaneo | Zendy; Cristina Gervasoni | Zendy; Paola Meraviglia | Zendy; Simona Landonio | Zendy; Serena Fucile | Zendy; Valeria Cozzi | Zendy; Sara Baldelli | Zendy; Marco Pellegrini | Zendy; Massimo Galli | Zendy; Emilio Clementi | Zendy

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Inter- and intra-patient variability of raltegravir pharmacokinetics in HIV-1-infected subjects

Author(s) -

Dario Cattaneo,

Cristina Gervasoni,

Paola Meraviglia,

Simona Landonio,

Serena Fucile,

Valeria Cozzi,

Sara Baldelli,

Marco Pellegrini,

Massimo Galli,

Emilio Clementi

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr498

Subject(s) - raltegravir , pharmacokinetics , medicine , therapeutic drug monitoring , pharmacology , concomitant , drug , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , virology

Limited studies in healthy volunteers and in HIV-1-infected patients have shown that raltegravir pharmacokinetics are characterized by high inter-patient variability. Only scanty data are, however, available on intra-patient raltegravir variability. The present study was designed to evaluate in parallel the inter- and intra-patient variability of raltegravir pharmacokinetics in HIV-1-infected patients during routine therapeutic drug monitoring (TDM).

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