Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica | Zendy

Gil M. Penuliar | Zendy; Atsushi Furukawa | Zendy; Kumiko NakadaTsukui | Zendy; Afzal Husain | Zendy; Dan Sato | Zendy; Tomoyoshi Nozaki | Zendy

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Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica

Author(s) -

Gil M. Penuliar,

Atsushi Furukawa,

Kumiko NakadaTsukui,

Afzal Husain,

Dan Sato,

Tomoyoshi Nozaki

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr484

Subject(s) - entamoeba histolytica , biology , transcriptome , gene , downregulation and upregulation , gene expression , drug resistance , microbiology and biotechnology , microarray analysis techniques , gene expression profiling , genetics

Drug resistance in parasitic protozoa is an obstacle to successful chemotherapy. Understanding how pathogens respond to drugs is crucial in preventing resistance. Previously, we have shown that in Entamoeba histolytica, methionine γ-lyase (EhMGL) downregulation results in trifluoromethionine resistance. The transcriptional response, however, of this parasite to the drug is not known. In this study, we used microarray analysis to determine whether additional genes are involved.

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