Open AccessAscorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics
Author(s) -
Jumana M. Yousef,
G. Chen,
Prue Hill,
Roger L. Nation,
Jian Li
Publication year - 2011
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr483
Subject(s) - ascorbic acid , colistin , nephrotoxicity , pharmacokinetics , pharmacology , excretion , chemistry , apoptosis , medicine , toxicity , biochemistry , antibiotics , food science
The use of colistin in the treatment of life-threatening Gram-negative infections is associated with a high rate of nephrotoxicity that is dose limiting. This study aimed to examine the nephroprotective effect of ascorbic acid against colistin-induced nephrotoxicity.
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