Could liposomal amphotericin B (L-AMB) lock solutions be useful to inhibit Candida spp. biofilms on silicone biomaterials? | Zendy

D. Toulet | Zendy; C. Debarre | Zendy; Christine Imbert | Zendy

Open Access

Could liposomal amphotericin B (L-AMB) lock solutions be useful to inhibit Candida spp. biofilms on silicone biomaterials?

Author(s) -

D. Toulet,

C. Debarre,

Christine Imbert

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr473

Subject(s) - candida albicans , candida glabrata , biofilm , amphotericin b , microbiology and biotechnology , candida parapsilosis , silicone , candida infections , lock (firearm) , antifungal , medicine , biology , chemistry , bacteria , mechanical engineering , genetics , organic chemistry , engineering

Candida infections associated with catheters remain difficult to manage. Antifungal lock strategies could be a therapeutic option when the device is difficult to remove or in combination with systemic treatment to increase efficacy. This study deals with the antibiofilm potential of liposomal amphotericin B (L-AMB) used as a lock solution to inhibit Candida albicans, Candida glabrata and Candida parapsilosis biofilms in vitro.

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