Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation | Zendy

Oriana Simonetti | Zendy; Oscar Cirioni | Zendy; Guendalina Lucarini | Zendy; Fiorenza Orlando | Zendy; Roberto Ghiselli | Zendy; Carmela Silvestri | Zendy; Lucia Brescini | Zendy; Marco Rocchi | Zendy; Mauro Provinciali | Zendy; Mario Guerrieri | Zendy; Roberto Di Primio | Zendy; Andrea Giacometti | Zendy; A. Offidani | Zendy

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Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation

Author(s) -

Oriana Simonetti,

Oscar Cirioni,

Guendalina Lucarini,

Fiorenza Orlando,

Roberto Ghiselli,

Carmela Silvestri,

Lucia Brescini,

Marco Rocchi,

Mauro Provinciali,

Mario Guerrieri,

Roberto Di Primio,

Andrea Giacometti,

A. Offidani

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr440

Subject(s) - teicoplanin , tigecycline , medicine , staphylococcus aureus , antibiotics , wound healing , microbiology and biotechnology , antimicrobial , surgery , pharmacology , vancomycin , biology , bacteria , genetics

We investigated the in vivo efficacy of tigecycline, a new glycylcycline (a tetracycline derivative), in the management of methicillin-resistant Staphylococcus aureus (MRSA)-infected experimental surgical wounds in rats. The main outcome measures were quantitative bacterial culture, histological examination and immunohistochemical expression of matrix metalloproteinase-9 (MMP-9) and collagen IV.

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