Open AccessOral bioavailability of moxifloxacin after Roux-en-Y gastric bypass surgery
Author(s) -
Julie Smet,
Pieter Colin,
Peter De Paepe,
Johannes Ruige,
Helene Batens,
Yves Van Nieuwenhove,
Dirk Vogelaers,
Stijn Blot,
Jan Van Bocxlaer,
Luc M. Van Bortel,
Koen Boussery
Publication year - 2011
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr436
Subject(s) - moxifloxacin , medicine , bioavailability , cmax , dosing , pharmacokinetics , oral administration , dose , crossover study , anesthesia , confidence interval , pharmacology , antibiotics , placebo , chemistry , biochemistry , alternative medicine , pathology
Roux-en-Y gastric bypass surgery is the most commonly performed procedure for the treatment of morbid obesity. This anatomical alteration may affect the absorption and consequently the bioavailability of oral drugs. This study aims to investigate the oral bioavailability of moxifloxacin in 12 healthy volunteers who underwent gastric bypass surgery.