CNS effects of a CCR5 inhibitor in HIV-infected subjects: a pharmacokinetic and cerebral metabolite study
Author(s) -
Lucy Garvey,
Mark Nelson,
Ngaire Latch,
O. W. Erlwein,
Joanna Allsop,
Alexis Mitchell,
Steve Kaye,
Victoria Watson,
D.J. Back,
Simon D. TaylorRobinson,
Alan Winston
Publication year - 2011
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr427
Subject(s) - maraviroc , lopinavir , ritonavir , metabolite , ccr5 receptor antagonist , pharmacokinetics , medicine , emtricitabine , pharmacology , chemistry , viral load , immunology , human immunodeficiency virus (hiv) , antiretroviral therapy , chemokine , receptor , chemokine receptor
We conducted a pharmacokinetic and in vivo cerebral (1)H magnetic resonance spectroscopy ((1)H-MRS) study to assess CSF exposure and cerebral metabolite ratios (CMRs) following maraviroc intensification.
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