Genetic characterization of an extended-spectrum AmpC cephalosporinase with hydrolysing activity against fourth-generation cephalosporins in a clinical isolate of Enterobacter aerogenes selected in vivo | Zendy

José Manuel Rodríguez-Martínez | Zendy; Pedro Fernández-Echauri | Zendy; Felipe Fernández-Cuenca | Zendy; Paula Díaz de Alba | Zendy; A. Briales | Zendy; Álvaro Pascual | Zendy

Open Access

Genetic characterization of an extended-spectrum AmpC cephalosporinase with hydrolysing activity against fourth-generation cephalosporins in a clinical isolate of Enterobacter aerogenes selected in vivo

Author(s) -

José Manuel Rodríguez-Martínez,

Pedro Fernández-Echauri,

Felipe Fernández-Cuenca,

Paula Díaz de Alba,

A. Briales,

Álvaro Pascual

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr423

Subject(s) - cefepime , cefpirome , ceftazidime , cephalosporin , enterobacter aerogenes , cloxacillin , microbiology and biotechnology , biology , enterobacter , escherichia coli , imipenem , antibiotics , antibiotic resistance , bacteria , biochemistry , pseudomonas aeruginosa , gene , genetics , ampicillin

Extended-spectrum AmpC cephalosporinases (ESACs) have been reported in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. Here, we characterize a new AmpC variant presenting a broadened substrate activity towards fourth-generation cephalosporins, selected in vivo following cefepime treatment for Enterobacter aerogenes.

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