Identification of hepatitis B virus rtS117F substitution as a compensatory mutation for rtM204I during lamivudine therapy | Zendy

ChihLang Lin | Zendy; RongNan Chien | Zendy; Chih-Fen Hu | Zendy; M. W. Lai | Zendy; ChauTing Yeh | Zendy

Open Access

Identification of hepatitis B virus rtS117F substitution as a compensatory mutation for rtM204I during lamivudine therapy

Author(s) -

ChihLang Lin,

RongNan Chien,

Chih-Fen Hu,

M. W. Lai,

ChauTing Yeh

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr416

Subject(s) - lamivudine , mutation , hepatitis b virus , mutant , virology , biology , mutagenesis , resistance mutation , virus , genetics , reverse transcriptase , polymerase chain reaction , gene

The replication defect of hepatitis B virus (HBV) lamivudine-resistant mutants can be restored by the development of compensatory mutations. Such mutations have long been recognized for the rtM204V mutant, while little is known about any compensatory mutation specific to the rtM204I mutant. The aim of this study was to search for previously unrecognized compensatory mutations following development of lamivudine-resistant mutants.

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