The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis | Zendy

Rosângela Rodrigues | Zendy; Karen S. Charret | Zendy; Catarina Campos | Zendy; Viviane Souza do Amaral | Zendy; Aurea Echevarrı́a | Zendy; Caroline Reis | Zendy; Marilene M. CantoCavalheiro | Zendy; Leonor L. Leon | Zendy

Open Access

The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis

Author(s) -

Rosângela Rodrigues,

Karen S. Charret,

Catarina Campos,

Viviane Souza do Amaral,

Aurea Echevarrı́a,

Caroline Reis,

Marilene M. CantoCavalheiro,

Leonor L. Leon

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr409

Subject(s) - mesoionic , leishmania infantum , in vivo , leishmania , trypanosoma cruzi , leishmaniasis , visceral leishmaniasis , in vitro , kinetoplastida , microbiology and biotechnology , biology , pharmacology , chemistry , virology , parasite hosting , immunology , protozoal disease , biochemistry , malaria , medicinal chemistry , world wide web , computer science

Researchers have recently investigated the biological activities of mesoionic (MI) compounds, which have shown in vitro activity against many species of Leishmania, as well as Trypanosoma cruzi. The main goal of this study was to evaluate and compare the activity of three MI compounds against Leishmania amazonensis and Leishmania infantum infection in vivo.

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