Plasma concentrations of efavirenz are associated with body weight in HIV-positive individuals | Zendy

Júlia Poeta | Zendy; Rafael Linden | Zendy; Marina Venzon Antunes | Zendy; Lúcia Helena Gonzales Real | Zendy; Andréia Magalhães de Menezes | Zendy; Jorge P. Ribeiro | Zendy; Eduardo Sprinz | Zendy

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Plasma concentrations of efavirenz are associated with body weight in HIV-positive individuals

Author(s) -

Júlia Poeta,

Rafael Linden,

Marina Venzon Antunes,

Lúcia Helena Gonzales Real,

Andréia Magalhães de Menezes,

Jorge P. Ribeiro,

Eduardo Sprinz

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr360

Subject(s) - efavirenz , body mass index , cohort , medicine , therapeutic drug monitoring , ambulatory , viral load , pharmacokinetics , gastroenterology , therapeutic index , pharmacology , antiretroviral therapy , human immunodeficiency virus (hiv) , immunology , drug

Efavirenz is among the most widely used antiretroviral drugs. Increased efavirenz exposure has been associated with CNS side effects and also with the chance of emergence of resistance upon treatment interruptions. The objective of this study was to evaluate factors associated with efavirenz plasma concentrations in a cohort of HIV-infected individuals.

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