Sodium butyrate inhibits pathogenic yeast growth and enhances the functions of macrophages
Author(s) -
Long N. Nguyen,
Livia Cristina Liporagi Lopes,
Radamés J. B. Cordero,
Joshua D. Nosanchuk
Publication year - 2011
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr358
Subject(s) - cryptococcus neoformans , microbiology and biotechnology , sodium butyrate , candida albicans , biology , corpus albicans , yeast , candida parapsilosis , virulence , butyrate , nitric oxide , biofilm , bacteria , biochemistry , fermentation , genetics , gene , endocrinology
Butyrate is a short-chain fatty acid that is produced by several human commensal bacteria, such as Clostridium and Lactobacillus species. Butyrate is also known to inhibit histone deacetylase. In this study we assessed the antifungal activity of sodium butyrate (SB) against the human pathogenic yeasts Candida albicans, Candida parapsilosis and Cryptococcus neoformans.
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