Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients | Zendy

Abiy Habtewold | Zendy; Wondwossen Amogne | Zendy; Eyasu Makonnen | Zendy; Getnet Yimer | Zendy; K. Riedel | Zendy; N. Ueda | Zendy; A. Worku | Zendy; Walter E. Haefeli | Zendy; Lars Lindquist | Zendy; Getachew Aderaye | Zendy; Jürgen Burhenne | Zendy; Eleni Aklillu | Zendy

Open Access

Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients

Author(s) -

Abiy Habtewold,

Wondwossen Amogne,

Eyasu Makonnen,

Getnet Yimer,

K. Riedel,

N. Ueda,

A. Worku,

Walter E. Haefeli,

Lars Lindquist,

Getachew Aderaye,

Jürgen Burhenne,

Eleni Aklillu

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr304

Subject(s) - efavirenz , peripheral blood mononuclear cell , ugt2b7 , pharmacology , drug , nevirapine , medicine , reverse transcriptase inhibitor , cyp2b6 , genotype , lamivudine , immunology , virology , pharmacokinetics , human immunodeficiency virus (hiv) , viral load , biology , antiretroviral therapy , cyp3a4 , in vitro , genetics , metabolism , glucuronidation , cytochrome p450 , gene , microsome , hepatitis b virus , virus

We investigated the long-term effect of efavirenz autoinduction on its plasma/peripheral blood mononuclear cell (PBMC) exposure and the CD4 count, and the importance of sex and pharmacogenetic variations.

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