Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens | Zendy

Christoph Wyen | Zendy; Heidy Hendra | Zendy; Marco Siccardi | Zendy; Martin Platten | Zendy; H. Jaeger | Zendy; Thomas Harrer | Zendy; Stefan Eßer | Zendy; Johannes R. Bogner | Zendy; Norbert H. Brockmeyer | Zendy; B Bieniek | Zendy; JK Rockstroh | Zendy; Christian Hoffmann | Zendy; Albrecht Stoehr | Zendy; Claudia Michalik | Zendy; Verena Dlugay | Zendy; Alexander Jetter | Zendy; Heribert Knechten | Zendy; Hartwig Klinker | Zendy; Adriane SkaletzRorowski | Zendy; Gerd Fätkenheuer | Zendy; David Egan | Zendy; David Back | Zendy; Andrew Owen | Zendy; S Dupke | Zendy; A Carganico | Zendy; A. Baumgarten | Zendy; S. Koeppe | Zendy; P. Kreckel | Zendy; Elke Lauenroth-Mai | Zendy; Frank Schlote | Zendy; Charles F. Schuler | Zendy; Matthias Freiwald | Zendy; Michael Rausch | Zendy; Jörg Gölz | Zendy; A. Moll | Zendy; Martin Zeitz | Zendy; Martin Hower | Zendy; Sven Reuter | Zendy; S Staszewski | Zendy; Andreas Plettenberg | Zendy; S. Fenske | Zendy; Thomas Buhk | Zendy; HansJürgen Stellbrink | Zendy; R. E. Schmidt | Zendy; Birger Kuhlmann | Zendy; Franz Mosthaf | Zendy; A. Rieke | Zendy; Stefan Scholten | Zendy; Eva Jaegel-Guedes | Zendy; R Volkert | Zendy; W. Becker | Zendy; H Hartl | Zendy; Antonius Mutz | Zendy; Albrecht Ulmer | Zendy; Bernhard Frietsch | Zendy; Mónika Müller | Zendy

Open Access

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

Author(s) -

Christoph Wyen,

Heidy Hendra,

Marco Siccardi,

Martin Platten,

H. Jaeger,

Thomas Harrer,

Stefan Eßer,

Johannes R. Bogner,

Norbert H. Brockmeyer,

B Bieniek,

JK Rockstroh,

Christian Hoffmann,

Albrecht Stoehr,

Claudia Michalik,

Verena Dlugay,

Alexander Jetter,

Heribert Knechten,

Hartwig Klinker,

Adriane SkaletzRorowski,

Gerd Fätkenheuer,

David Egan,

David Back,

Andrew Owen,

S Dupke,

A Carganico,

A. Baumgarten,

S. Koeppe,

P. Kreckel,

Elke Lauenroth-Mai,

Frank Schlote,

Charles F. Schuler,

Matthias Freiwald,

Michael Rausch,

Jörg Gölz,

A. Moll,

Martin Zeitz,

Martin Hower,

Sven Reuter,

S Staszewski,

Andreas Plettenberg,

S. Fenske,

Thomas Buhk,

HansJürgen Stellbrink,

R. E. Schmidt,

Birger Kuhlmann,

Franz Mosthaf,

A. Rieke,

Stefan Scholten,

Eva Jaegel-Guedes,

R Volkert,

W. Becker,

H Hartl,

Antonius Mutz,

Albrecht Ulmer,

Bernhard Frietsch,

Mónika Müller

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr272

Subject(s) - efavirenz , cyp2b6 , discontinuation , medicine , constitutive androstane receptor , pharmacology , cyp3a4 , gastroenterology , oncology , biology , cytochrome p450 , immunology , genetics , viral load , nuclear receptor , metabolism , human immunodeficiency virus (hiv) , antiretroviral therapy , transcription factor , gene

Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in the CYP2B6 gene are associated with efavirenz pharmacokinetics. Since the constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) correlate with CYP2B6 in liver, and a CAR polymorphism (rs2307424) and smoking correlate with efavirenz plasma concentrations, we investigated their association with early (<3 months) discontinuation of efavirenz therapy.

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