Structure–function relationships of CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii | Zendy

Manuella CatelFerreira | Zendy; Gaël Coadou | Zendy; Virginie Molle | Zendy; Pauline Mugnier | Zendy; Patrice Nordmann | Zendy; Axel Siroy | Zendy; Thierry Jouenne | Zendy; Emmanuelle Dé | Zendy

Open Access

Structure–function relationships of CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii

Author(s) -

Manuella CatelFerreira,

Gaël Coadou,

Virginie Molle,

Pauline Mugnier,

Patrice Nordmann,

Axel Siroy,

Thierry Jouenne,

Emmanuelle Dé

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr267

Subject(s) - porin , acinetobacter baumannii , microbiology and biotechnology , bacterial outer membrane , imipenem , context (archaeology) , carbapenem , acinetobacter , biology , antibiotic resistance , bacteria , antibiotics , pseudomonas aeruginosa , gene , genetics , escherichia coli , paleontology

In the context of the increasing worldwide occurrence of imipenem-resistant Acinetobacter baumannii strains, we investigated a possible porin-mediated mechanism relating to the carbapenem resistance-associated outer membrane protein, CarO. The aim of this study was to determine whether this porin may be a diffusion pathway for carbapenems in A. baumannii.

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