Vancomycin-resistant enterococcal bacteraemia and daptomycin: are higher doses necessary? | Zendy

E. A. King | Zendy; Dorothy McCoy | Zendy; Suneel Ramesh Desai | Zendy; Themba Nyirenda | Zendy; Keri Bicking | Zendy

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Vancomycin-resistant enterococcal bacteraemia and daptomycin: are higher doses necessary?

Author(s) -

E. A. King,

Dorothy McCoy,

Suneel Ramesh Desai,

Themba Nyirenda,

Keri Bicking

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr255

Subject(s) - daptomycin , medicine , vancomycin , bacteremia , minimum inhibitory concentration , enterococcus , incidence (geometry) , retrospective cohort study , enterococcus faecalis , surgery , antibiotics , microbiology and biotechnology , staphylococcus aureus , biology , bacteria , physics , optics , genetics

The MIC corresponding to daptomycin susceptibility for vancomycin-resistant enterococci (VRE) is ≤ 4 mg/L. Based on the concentration-dependent killing properties of daptomycin, there may be concern about achieving adequate concentrations when the MIC approaches the upper end of the susceptible range (3-4 mg/L). Higher doses of daptomycin may be needed to treat VRE isolates with higher MICs.

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