Impact of a clonal outbreak of extended-spectrum -lactamase-producing Klebsiella pneumoniae in the development and evolution of bloodstream infections by K. pneumoniae and Escherichia coli: an 11 year experience in Oxfordshire, UK | Zendy

D. P. Webster | Zendy; Bernadette C. Young | Zendy; Randall P. Morton | Zendy; D. Collyer | Zendy; B. Batchelor | Zendy; Jane F. Turton | Zendy; Sunil Maharjan | Zendy; David M. Livermore | Zendy; Philip Bejon | Zendy; B Cookson | Zendy; I.C.J.W. Bowler | Zendy

Open Access

Impact of a clonal outbreak of extended-spectrum -lactamase-producing Klebsiella pneumoniae in the development and evolution of bloodstream infections by K. pneumoniae and Escherichia coli: an 11 year experience in Oxfordshire, UK

Author(s) -

D. P. Webster,

Bernadette C. Young,

Randall P. Morton,

D. Collyer,

B. Batchelor,

Jane F. Turton,

Sunil Maharjan,

David M. Livermore,

Philip Bejon,

B Cookson,

I.C.J.W. Bowler

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr246

Subject(s) - klebsiella pneumoniae , outbreak , multilocus sequence typing , microbiology and biotechnology , multiple drug resistance , antibiotic resistance , biology , population , drug resistance , escherichia coli , antibiotics , virology , medicine , genotype , environmental health , genetics , gene

The objectives of this study were: (i) to describe an outbreak of multidrug-resistant Klebsiella pneumoniae in our population; (ii) to identify the potential source of this outbreak by examining antibiotic resistance trends in urocultures; (iii) to evaluate the contribution of this outbreak to resistance patterns over time in the two commonest Gram-negative blood culture isolates, namely K. pneumoniae and Escherichia coli; and (iv) to assess risk factors for multidrug resistance and the impact of this resistance on mortality and length of stay.

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