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Eradication of carriage with methicillin-resistant Staphylococcus aureus: effectiveness of a national guideline
Author(s) -
Heidi S. M. Ammerlaan,
Jan Kluytmans,
Hanneke Berkhout,
A. G. M. Buiting,
E. I. G. B. de Brauwer,
P.J. van den Broek,
Paula van Gelderen,
Sander C. A. P. Leenders,
Alewijn Ott,
Clemens Richter,
Lodewijk Spanjaard,
Ingrid J. B. Spijkerman,
Frank H. van Tiel,
G. Paul Voorn,
M.W.H. Wulf,
Jan van Zeijl,
Annet Troelstra,
Marc J. M. Bonten,
C Berg,
J. Bosman,
Andreas Bremer,
W. Bril,
D. Commeren,
G. van Essen,
A. Gigengack-Baars,
M. M. E. van Kasteren,
E. J. M. Lommerse,
Ellen M. Mascini,
Nicole H. M. Renders,
M. van Rijen,
Jeroen J. A. Schellekens,
E. Smeets,
T. Sprangers,
Christina M. J. E. VandenbrouckeGrauls,
Annelies Verbon,
Kees Verduin,
J. H. T. Wagenvoort,
Peter van Wijngaarden
Publication year - 2011
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr243
Subject(s) - mupirocin , medicine , carriage , guideline , methicillin resistant staphylococcus aureus , interquartile range , antibiotics , staphylococcus aureus , surgery , intensive care medicine , microbiology and biotechnology , pathology , biology , bacteria , genetics
We evaluated the effectiveness of eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage in the Netherlands after the introduction of a guideline in 2006. The guideline distinguishes complicated (defined as the presence of MRSA infection, skin lesions, foreign-body material, mupirocin resistance and/or exclusive extranasal carriage) and uncomplicated carriage (not meeting criteria for complicated carriage). Mupirocin nasal ointment and chlorhexidine soap solution are recommended for uncomplicated carriers and the same treatment in combination with two oral antibiotics for complicated carriage.

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