Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukaemia | Zendy

R. M. van Schie | Zendy; Roger J. M. Brüggemann | Zendy; P.M. Hoogerbrugge | Zendy; D. Maroeska W. M. te Loo | Zendy

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Effect of azole antifungal therapy on vincristine toxicity in childhood acute lymphoblastic leukaemia

Author(s) -

R. M. van Schie,

Roger J. M. Brüggemann,

P.M. Hoogerbrugge,

D. Maroeska W. M. te Loo

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr223

Subject(s) - azole , toxicity , vincristine , medicine , antifungal , pharmacology , lymphoblastic leukemia , chemotherapy , acute lymphocytic leukemia , leukemia , dermatology , cyclophosphamide

Vincristine is one of the cornerstones of the treatment of children with acute lymphoblastic leukaemia (ALL). Constipation, and peripheral and central neurotoxicities are the most common side effects. A comparative study exploring vincristine toxicity in individual patients receiving vincristine with and without azoles, however, is lacking.

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