Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models | Zendy

Zahoor Ahmad | Zendy; Mostafa Fraig | Zendy; Michael L. Pinn | Zendy; Sandeep Tyagi | Zendy; Eric L. Nuermberger | Zendy; J Grosset | Zendy; Petros C. Karakousis | Zendy

Open Access

Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models

Author(s) -

Zahoor Ahmad,

Mostafa Fraig,

Michael L. Pinn,

Sandeep Tyagi,

Eric L. Nuermberger,

J Grosset,

Petros C. Karakousis

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr188

Subject(s) - pyrazinamide , tuberculosis , rifampicin , caseous necrosis , isoniazid , mycobacterium tuberculosis , guinea pig , medicine , lung , pathology , caviidae , immunology , biology

It is widely believed that persistent Mycobacterium tuberculosis inhabits necrotic lung granulomas in humans and that the microenvironmental conditions encountered therein render the bacilli phenotypically tolerant to antibiotics, accounting for the long duration required for successful treatment of tuberculosis (TB). To validate this belief, we directly compared the activity of rifampicin/isoniazid/pyrazinamide (RHZ) against chronic TB infection in guinea pigs, which exhibit caseous granulomas histologically resembling human caseous foci, and in mice, which lack necrotic granulomas.

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