Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study | Zendy

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Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Author(s) -

Mattia Prosperi,

Nicola Mackie,

Simona Di Giambenedetto,

Maurizio Zazzi,

Ricardo Camacho,

Iuri Fanti,

Carlo Torti,

Anders Sönnerborg,

Rolf Kaiser,

Francisco M. Codoñer,

Kristel Van Laethem,

Clifford Leen,

David van de Vijver,

Anna María Geretti,

Andrea De Luca,

Maria Carla Re,

Luca Butini,

Romana del Gobbo,

Stefano Menzo,

Danilo Tacconi,

Giovanni Corbelli,

Stefania Zanussi,

Laura Monno,

Grazia Punzi,

F Maggiolo,

Annapaola Callegaro,

Leonardo Calza,

R. Pristerà,

Paola Turconi,

Antonella Mandas,

Sauro Tini,

Alessia Zoncada,

Elisabetta Paolini,

Giorgio Amadio,

Laura Sighinolfi,

Giuliano Zuccati,

Massimo Morfini,

Roberto Manetti,

Paola Corsi,

Laura Galli,

Massimo Di Pietro,

Filippo Bartalesi,

G Colao,

Andrea Tosti,

Antonio Di Biagio,

Maurizio Setti,

Bianca Bruzzone,

Giovanni Penco,

Michele Trezzi,

Anna Orani,

Riccardo Pardelli,

Michele De Gennaro,

Alessandro Chiodera,

Alfredo Scalzini,

Loredana Palvarini,

P Almi,

Giovanni Todaro,

Antonella d’Arminio Monforte,

Paola Cicconi,

Stefano Rusconi,

Maria Rita Gismondo,

Valeria Micheli,

Maria Luisa Biondi,

Nicola Gianotti,

Amedeo Capetti,

Paola Meraviglia,

Enzo Boeri,

Cristina Mussini,

Monica Pecorari,

Alessandro Soria,

Laura Vecchi,

Maurizio Santirocchi,

Diego Brustia,

Paolo Ravanini,

Federico Dal Bello,

Nino Romano,

Salvatrice Mancuso,

Carlo Calzetti,

Renato Maserati,

G. Filice,

Fausto Baldanti,

Daniela Francisci,

Giustino Parruti,

Ennio Polilli,

D. Sacchini,

Chiara Martinelli,

Rita Consolini,

Linda Vatteroni,

A Vivarelli,

Daniele Dionisio,

Alessandro Nerli,

Lucia Lenzi,

G. Magnani,

P Ortolani,

Massimo Andreoni,

Guido Palamara,

Caterina Fimiani,

Lucia Palmisano,

Giovanni Fadda,

Vincenzo Vullo,

Ombretta Turriziani,

Marco Aurélio Echart Montano,

Giovanni Cenderello,

Angela Gonnelli,

Michele Palumbo,

Valeria Ghisetti,

Stefano Bonora,

Palma Delle Foglie,

Cristina Rossi,

Paolo Grossi,

Elena Seminari,

Federica Poletti,

Vincenzo Mondino,

Marina Malena,

Emanuela Lattuada,

Thomas Lengauer,

Martin Däumer,

Daniel Hoffmann,

Eugen Schülter,

Claudia Müller,

Mark Oette,

Stefan Reuter,

Stefan Esser,

Gerd Fätkenheuer,

Jürgen K. Rockstroh,

Francesca Incardona,

Michal RosenZvi,

Bonaventura Clotet,

Anders Thalme,

Veronica Svedhem,

Göran Bratt,

Franco Gargiulo,

Giuseppe Lapadula,

N. Manca,

Giuseppe Paraninfo,

Eugenia Quirós-Roldán,

Giampiero Carosi,

Filippo Castelnuovo,

Anne–Mieke Vandamme,

Eric Van Wijngaerden,

Jonathan Ainsworth,

Jane Anderson,

Abdel Babiker,

David Dunn,

Philippa Easterbrook,

Fabiola Martin,

Brian Gazzard,

Nigel Garrett,

Richard Gilson,

Mark Gompels,

Teresa Hill,

Margaret Johnson,

Chloe Orkin,

Andrew Phillips,

Deenan Pillay,

Kholoud Porter,

Frank A. Post,

Caroline Sabin,

S Tariq Sadiq,

Achim Schwenk,

John Walsh,

Valérie Delpech,

Adrian Palfreeman,

Adam Glabay,

Janet Lynch,

James Hand,

Carl de Souza,

Nicky Perry,

Stuart Tilbury,

Duncan Churchill,

Mark Nelson,

Matthew Waxman,

Sundhiya Mandalia,

Meaghan Kall,

Hardik Korat,

Chris Taylor,

Fowzia Ibrahim,

Lucy J. Campbell,

Laura James,

Nataliya Brima,

Ian Williams,

Mike Youle,

Fiona Lampe,

Colette Smith,

Helen Grabowska,

Clinton Chaloner,

Dewi Ismajani Puradiredja,

Jonathan Weber,

Farhan Ramzan,

Mark Carder,

Alan C. Wilson,

Debbie Dooley,

David Asboe,

Anton Pozniak,

Sheila Cameron,

Patricia Cane,

David Chadwick,

Duncan A. Clark,

Simon Collins,

Linda Lazarus,

David Dolling,

Esther Fearnhill,

Hannah Castro,

Kate Coughlin,

Mark Zuckerman,

Geretti Anna Maria,

Clare Booth,

David Goldberg,

Antony Hale,

Steve Kaye,

Paul Kellam,

Andrew Brown,

Erasmus Smit,

Kate Templeton,

Peter Tilston,

William G. Tong,

Hongyi Zhang,

Ines UshiroLumb,

Tony Oliver,

David Bibby,

Suzanne Mitchell,

Tamyo Mbisa,

Adrian Wildfire,

Richard D. Tandy,

Jill Shepherd,

Alasdair Maclean,

Diane Bennett,

Mark Hopkins,

Ana Garcı́a-Dı́az,

Stuart A. Kirk

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr171

Subject(s) - viral load , drug resistance , cohort , medicine , hiv drug resistance , virology , drug , lentivirus , human immunodeficiency virus (hiv) , genotype , cohort study , immunology , antiretroviral therapy , viral disease , pharmacology , biology , genetics , gene

Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.

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