Comparison of clinical isolates and in vitro selected mutants reveals that tlyA is not a sensitive genetic marker for capreomycin resistance in Mycobacterium tuberculosis | Zendy

A. Engström | Zendy; Nasrin Perskvist | Zendy; Jim Werngren | Zendy; Sven Hoffner | Zendy; Pontus Juréen | Zendy

Open Access

Comparison of clinical isolates and in vitro selected mutants reveals that tlyA is not a sensitive genetic marker for capreomycin resistance in Mycobacterium tuberculosis

Author(s) -

A. Engström,

Nasrin Perskvist,

Jim Werngren,

Sven Hoffner,

Pontus Juréen

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr109

Subject(s) - capreomycin , kanamycin , amikacin , mycobacterium tuberculosis , biology , microbiology and biotechnology , mutant , genetics , tuberculosis , medicine , gene , streptomycin , antibiotics , ethambutol , pathology

The aim of this study was to clarify the conflicting data regarding cross-resistance and drug-resistance mechanisms for the cyclic peptide capreomycin and the aminoglycosides amikacin and kanamycin by comparing genotypes and phenotypes of clinical isolates and in vitro selected mutants of Mycobacterium tuberculosis.

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