Artesunate enhances the antibacterial effect of β-lactam antibiotics against Escherichia coli by increasing antibiotic accumulation via inhibition of the multidrug efflux pump system AcrAB-TolC | Zendy

Bin Li | Zendy; Qi Yao | Zendy; Xichun Pan | Zendy; Ning Wang | Zendy; Rong Zhang | Zendy; Jun Li | Zendy; Guo-Fu Ding | Zendy; Xin Liu | Zendy; Chong Wu | Zendy; Dongzhi Ran | Zendy; Jiang Zheng | Zendy; Hong Zhou | Zendy

Open Access

Artesunate enhances the antibacterial effect of β-lactam antibiotics against Escherichia coli by increasing antibiotic accumulation via inhibition of the multidrug efflux pump system AcrAB-TolC

Author(s) -

Bin Li,

Qi Yao,

Xichun Pan,

Ning Wang,

Rong Zhang,

Jun Li,

Guo-Fu Ding,

Xin Liu,

Chong Wu,

Dongzhi Ran,

Jiang Zheng,

Hong Zhou

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr017

Subject(s) - artesunate , efflux , antibiotics , escherichia coli , microbiology and biotechnology , antibacterial activity , antibacterial agent , enterobacteriaceae , biology , pharmacology , chemistry , bacteria , biochemistry , gene , immunology , plasmodium falciparum , genetics , malaria

Occasionally, we found that artesunate enhanced the antibacterial effects of antibiotics in vitro. Therefore, the enhancement of various β-lactam antibiotics by artesunate against Escherichia coli and the possible mechanism were investigated in the present study.

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