Comparative evaluation of synergy of combinations of -lactams with fluoroquinolones or a macrolide in Streptococcus pneumoniae | Zendy

Lorenzo Drago | Zendy; L. Nicola | Zendy; Valentina Rodighiero | Zendy; Monica Larosa | Zendy; R. Mattina | Zendy; Elena De Vecchi | Zendy

Open Access

Comparative evaluation of synergy of combinations of -lactams with fluoroquinolones or a macrolide in Streptococcus pneumoniae

Author(s) -

Lorenzo Drago,

L. Nicola,

Valentina Rodighiero,

Monica Larosa,

R. Mattina,

Elena De Vecchi

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr016

Subject(s) - levofloxacin , clavulanic acid , penicillin , clarithromycin , microbiology and biotechnology , amoxicillin , streptococcus pneumoniae , antibiotics , cephalosporin , trovafloxacin , ceftriaxone , ofloxacin , medicine , antibacterial agent , pharmacology , biology , ciprofloxacin

Streptococcus pneumoniae has shown a great ability to develop efficacious mechanisms of resistance to the main drugs for the treatment of pneumonia, such as β-lactams, macrolides and fluoroquinolones. The present study aimed to compare the antipneumococcal activity of combinations of respiratory fluoroquinolones with cephalosporins (either parenteral or oral) or protected penicillin versus the standard combinations (i.e. a macrolide with a protected penicillin or cephalosporin) against 100 isolates with different susceptibilities to macrolides and/or penicillin.

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