Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy | Zendy

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Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy

Author(s) -

WP Bannister,

Alessandro CozziLepri,

Jesper Kjær,

B Clotet,

Adriano Lazzarin,

J.-P. Viard,

Gitte Kronborg,

Dan Duiculescu,

Marek Beniowski,

Ladislav Machala,

Andrew Phillips,

M Losso,

Christelle Elias,

N. Vetter,

Robert Zangerle,

Igor Karpov,

Anna Vassilenko,

В. М. Мицура,

O. Suetnov,

Nathan Clumeck,

S. De Wit,

M Delforge,

Robert Colebunders,

Linos Vandekerckhove,

Vesna Hadžiosmanović,

Kosta Kostov,

Josip Begovać,

H Rozsypal,

Dalibor Sedláček,

Jens Nielsen,

Thomas Benfield,

MV Larsen,

J Gerstoft,

Terese L. Katzenstein,

BR Hansen,

Peter Skinhøj,

C. Pedersen,

Lars Oestergaard,

Kai Zilmer,

Jelena Šmidt,

Matti Ristola,

Christine Katlama,

JeanPaul Viard,

Pierre Marie Girard,

J. M. Livrozet,

Philippe Vanhems,

Christian Pradier,

François Dabis,

D. Neau,

Jürgen K. Rockstroh,

Robert L. Schmidt,

Jan van Lunzen,

Olaf Degen,

HJ Stellbrink,

S Staszewski,

John W. Goethe,

J. R. Bogner,

G Fätkenheuer,

J. Kosmidis,

Panagiotis Gargalianos,

G. Xylomenos,

J. Perdios,

George Panos,

A. Filandras,

E. Karabatsaki,

Dénes Bánhegyi,

F Mulcahy,

Israel Yust,

Dianna Turner,

Michael Burke,

S Pollack,

Gamal Hassoun,

Shlomo Maayan,

Antonio Chiesi,

Roberto Esposito,

I. Mazeu,

Cristina Mussini,

Claudio Arici,

R. Pristerà,

Francesco Mazzotta,

Andrea Gabbuti,

Vincenzo Vullo,

Miriam Lichtner,

Antonio Chirianni,

E. Montesarchio,

Miriam Gargiulo,

G. Antonucci,

Fabio Iacomi,

Pasquale Narciso,

Chrysoula Vlassi,

Maria Carla Re,

Renato Finazzi,

Massimo Galli,

Anna Lisa Ridolfo,

Antonella d’Arminio Monforte,

Baiba Rozentāle,

Indra Zeltiņa,

Saulius Chaplinskas,

R Hemmer,

Thérèse Staub,

Peter Reiss,

JN Bruun,

A Mæland,

Vidar Ormaasen,

Brygida Knysz,

Jacek Gąsiorowski,

Andrzéj Horban,

Elżbieta Bąkowska,

Anna Grzeszczuk,

Robert Flisiak,

Anna BorońKaczmarska,

M. Pynka,

E. Mularska,

H Trocha,

Elżbieta Jabłonowska,

Ewa Małolepsza,

Kamila Wójcik,

Francisco Antunes,

Emília Valadas,

Kamal Mansinho,

Fernando Maltêz,

Aza Rakhmanova,

Elena Vinogradova,

Djordje Jevtović,

M Mokrás,

D Staneková,

Janez Tomažič,

Juan GonzálezLahoz,

Vincent Soriano,

Pablo Labarga,

J. Medraño,

Santiago Moreno,

Bonaventura Clotet,

Antoni Jou,

Roger Paredes,

C. Tural,

Javier Juega Puig,

Isabel Bravo,

José M. Gatell,

Joaquim Miró,

Peré Domingo,

María Luisa Navarro Gómez,

Gràcia Mateo,

M. A. Sambeat,

Anna Karlsson,

Bruno Ledergerber,

Rainer Weber,

Bernard Hirschel,

E. Boffi,

Hansjakob Furrer,

Manuel Battegay,

Luigia Elzi,

Елена Николаевна Кравченко,

Nelly Chentsova,

S. Servitskiy,

Sergii Antoniak,

Максим Ігорович Краснов,

Simon Barton,

Margaret Johnson,

D Mercey,

Amanda Mocroft,

M. Murphy,

Jonathan Weber,

G Scullard,

Martin Fisher,

Clifford Leen,

Brian Gazzard,

Antonella D’Arminio Montforte,

Jens Lundgren,

O. Kirk,

Nina FriisMøller,

Wendy Bannister,

Mark Ellefson,

Annie Borch,

Daria Podlekareva,

Lars Peters,

J. Reekie,

Justyna D. Kowalska

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkr006

Subject(s) - hiv drug resistance , confidence interval , medicine , drug resistance , logistic regression , cohort , viral load , cohort study , virology , human immunodeficiency virus (hiv) , antiretroviral therapy , biology , microbiology and biotechnology

Estimating the prevalence of accumulated HIV drug resistance in patients receiving antiretroviral therapy (ART) is difficult due to lack of resistance testing at all occasions of virological failure and in patients with undetectable viral load. A method to estimate this for 6498 EuroSIDA patients who were under follow-up on ART at 1 July 2008 was therefore developed by imputing data on patients with no prior resistance test results, based on the probability of detecting resistance in tested patients with similar profiles.

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