Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants | Zendy

Sudeshna Kar | Zendy; Gunjan Sharma | Zendy; P.K. Das | Zendy

Open Access

Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants

Author(s) -

Sudeshna Kar,

Gunjan Sharma,

P.K. Das

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq502

Subject(s) - leishmania donovani , macrophage , microbiology and biotechnology , fucoidan , leishmania , biology , virology , immunology , leishmaniasis , in vitro , visceral leishmaniasis , parasite hosting , biochemistry , polysaccharide , world wide web , computer science

The aim of this study was to evaluate and characterize the antileishmanial efficacy of fucoidan, a polyanionic sulphated polysaccharide from brown algae, in experimental infections of BALB/c mice with antimony-susceptible (AG83) and -resistant (GE18ER) Leishmania donovani.

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