Potential of novel antiretrovirals to modulate expression and function of drug transporters in vitro | Zendy

Nadine Cécile Luise Zembruski | Zendy; Gabriele Büchel | Zendy; L. Jodicke | Zendy; Melanie Herzog | Zendy; Walter E. Haefeli | Zendy; Johanna Weiß | Zendy

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Potential of novel antiretrovirals to modulate expression and function of drug transporters in vitro

Author(s) -

Nadine Cécile Luise Zembruski,

Gabriele Büchel,

L. Jodicke,

Melanie Herzog,

Walter E. Haefeli,

Johanna Weiß

Publication year - 2011

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq501

Subject(s) - raltegravir , elvitegravir , abcg2 , multidrug resistance associated protein 2 , pharmacology , atp binding cassette transporter , maraviroc , transporter , efflux , p glycoprotein , biology , multiple drug resistance , chemistry , drug resistance , biochemistry , virology , viral load , microbiology and biotechnology , human immunodeficiency virus (hiv) , antiretroviral therapy , gene

The chemokine receptor antagonists maraviroc and vicriviroc and the integrase inhibitors elvitegravir and raltegravir are novel antiretroviral agents for the treatment of HIV-1 infections. ATP-binding cassette (ABC) transporters as modulators of the effectiveness and safety of therapy can mediate viral resistance and drug-drug interactions. To expand knowledge on drug-drug interactions of these antiretrovirals we investigated whether these compounds are substrates, inhibitors or inducers of important ABC transporters.

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