PCR-based amplification of heterogeneous IS257-ileS2 junctions for molecular monitoring of high-level mupirocin resistance in staphylococci | Zendy

Eduardo Pérez-Roth | Zendy; Estefanía ArmasGonzález | Zendy; Julia Alcoba-Flórez | Zendy; Sebastián Méndez-Álvarez | Zendy

Open Access

PCR-based amplification of heterogeneous IS257-ileS2 junctions for molecular monitoring of high-level mupirocin resistance in staphylococci

Author(s) -

Eduardo Pérez-Roth,

Estefanía ArmasGonzález,

Julia Alcoba-Flórez,

Sebastián Méndez-Álvarez

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq493

Subject(s) - mupirocin , microbiology and biotechnology , staphylococcus aureus , biology , medicine , bacteria , methicillin resistant staphylococcus aureus , genetics

Plasmids encoding the ileS2 gene are responsible for the wide spread of high-level mupirocin resistance in staphylococci, and consequent clinical and epidemiological problems. We investigated the location of insertion sequence IS257 flanking ileS2 in different plasmids and developed a method for molecular typing of the IS257-ileS2 spacer regions.

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