Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness | Zendy

Daniel Brookes | Zendy; Shahjahan Miah | Zendy; Angie Lackenby | Zendy; Lorian C. Hartgroves | Zendy; William Barclay | Zendy

Open Access

Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness

Author(s) -

Daniel Brookes,

Shahjahan Miah,

Angie Lackenby,

Lorian C. Hartgroves,

William Barclay

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq486

Subject(s) - neuraminidase , oseltamivir , virology , pandemic , virus , h5n1 genetic structure , microbiology and biotechnology , biology , influenza a virus , neuraminidase inhibitor , resistance mutation , mutation , enzyme , covid-19 , medicine , genetics , gene , polymerase chain reaction , reverse transcriptase , disease , pathology , infectious disease (medical specialty) , biochemistry

Resistance to the neuraminidase inhibitor oseltamivir can be conferred by a well-characterized mutation in the neuraminidase gene, H275Y. In human H1N1 viruses that circulated in the first years of the 21st century, this mutation carried a fitness cost and resistant viruses were rare. During the 2007-08 influenza season, oseltamivir-resistant viruses of H1N1 phenotype emerged and predominated. March 2009 saw the emergence of a novel H1N1 influenza pandemic. We examined whether the H275Y mutation affected neuraminidase enzyme activity or replication of the pandemic influenza virus.

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