Molecular characterization and phylogenetic analysis of quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE gene loci in viridans group streptococci isolated from adult patients with cystic fibrosis | Zendy

Yorinobu Maeda | Zendy; M. Murayama | Zendy; C. E. Goldsmith | Zendy; W. A. Coulter | Zendy; C. Mason | Zendy; B. Cherie Millar | Zendy; James Dooley | Zendy; Colm J. Lowery | Zendy; Motoo Matsuda | Zendy; J. Rendall | Zendy; J.S. Elborn | Zendy; John E. Moore | Zendy

Open Access

Molecular characterization and phylogenetic analysis of quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE gene loci in viridans group streptococci isolated from adult patients with cystic fibrosis

Author(s) -

Yorinobu Maeda,

M. Murayama,

C. E. Goldsmith,

W. A. Coulter,

C. Mason,

B. Cherie Millar,

James Dooley,

Colm J. Lowery,

Motoo Matsuda,

J. Rendall,

J.S. Elborn,

John E. Moore

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq485

Subject(s) - streptococcus oralis , microbiology and biotechnology , streptococcus sanguinis , ciprofloxacin , streptococcus anginosus , biology , streptococcus mitis , streptococcus salivarius , streptococcus gordonii , streptococcus , quinolone , viridans streptococci , pseudomonas aeruginosa , streptococcus mutans , streptococcaceae , genetics , antibiotics , bacteria

Ciprofloxacin is the most frequently used member of the fluoroquinolones during initial eradication therapy of Pseudomonas aeruginosa, as well as during acute pulmonary exacerbations. However, its long-term effect on the susceptibility of the commensal flora within the cystic fibrosis (CF) airways has not yet been examined. The aim of this study was therefore to examine the consequence of oral ciprofloxacin usage on the resistance of the commensal viridans group streptococci (VGS), in terms of MICs and mutational analysis of the quinolone resistance-determining regions (QRDRs).

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