Efficacy of carbapenems against a metallo- -lactamase-producing Escherichia coli clinical isolate in a rabbit intra-abdominal abscess model | Zendy

Maria Souli | Zendy; Elisavet Konstantinidou | Zendy; IraMaria Tzepi | Zendy; Θωμάς Τσαγανός | Zendy; Angelos Pefanis | Zendy; Zoi Chryssouli | Zendy; Irene Galani | Zendy; Evangelos J. GiamarellosBourboulis | Zendy; Helen Giamarellou | Zendy

Open Access

Efficacy of carbapenems against a metallo- -lactamase-producing Escherichia coli clinical isolate in a rabbit intra-abdominal abscess model

Author(s) -

Maria Souli,

Elisavet Konstantinidou,

IraMaria Tzepi,

Θωμάς Τσαγανός,

Angelos Pefanis,

Zoi Chryssouli,

Irene Galani,

Evangelos J. GiamarellosBourboulis,

Helen Giamarellou

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq470

Subject(s) - ertapenem , aztreonam , imipenem , meropenem , microbiology and biotechnology , carbapenem , escherichia coli , enterobacteriaceae , klebsiella pneumoniae , cephalosporin , medicine , biology , antibiotics , antibiotic resistance , biochemistry , gene

Although metallo-β-lactamases (MBLs) hydrolyse most β-lactams, including carbapenems, MBL-producing Enterobacteriaceae very often remain susceptible to carbapenems in vitro. We studied the in vivo efficacy of imipenem, meropenem, ertapenem and aztreonam against a carbapenem-susceptible MBL-producing clinical Escherichia coli strain in a rabbit intra-abdominal abscess model.

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