In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species | Zendy

Raquel Inocêncio da Luz | Zendy; M Vermeersch | Zendy; Maartje Deschacht | Zendy; Sarah Hendrickx | Zendy; Tim Van Assche | Zendy; Paul Cos | Zendy; Louis Maes | Zendy

Open Access

In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species

Author(s) -

Raquel Inocêncio da Luz,

M Vermeersch,

Maartje Deschacht,

Sarah Hendrickx,

Tim Van Assche,

Paul Cos,

Louis Maes

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq444

Subject(s) - cutaneous leishmaniasis , amastigote , in vivo , leishmania , saponin , in vitro , triterpene , leishmania mexicana , pharmacology , biology , leishmaniasis , medicine , immunology , pathology , biochemistry , parasite hosting , alternative medicine , microbiology and biotechnology , world wide web , computer science

The oleanane triterpene saponin PX-6518, with known potent in vitro and in vivo activity against Leishmania donovani, was investigated for its spectrum against the cutaneous species Leishmania mexicana, Leishmania panamensis and Leishmania major.

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