Efavirenz concentrations in CSF exceed IC50 for wild-type HIV | Zendy

Brookie M. Best | Zendy; P.P. Koopmans | Zendy; Scott Letendre | Zendy; Edmund V. Capparelli | Zendy; Steven S. Rossi | Zendy; David B. Clifford | Zendy; Ann C. Collier | Zendy; Benjamin B. Gelman | Zendy; Gilbert Mbeo | Zendy; J. Allen McCutchan | Zendy; David M. Simpson | Zendy; Richard Haubrich | Zendy; Ronald J. Ellis | Zendy; Igor Grant | Zendy; Thomas D. Marcotte | Zendy; Donald Franklin | Zendy; Thomas S. Alexander | Zendy; Robert K. Heaton | Zendy; J. Hampton Atkinson | Zendy; Steven Paul Woods | Zendy; M. Dawson | Zendy; Jacqueline Wong | Zendy; Christine FennemaNotestine | Zendy; Matthew Taylor | Zendy; Rebecca J. Theilmann | Zendy; Anthony Gamst | Zendy; Clint Cushman | Zendy; Ian Abramson | Zendy; Florin Vaida | Zendy; R. Jaeger | Zendy; Justin C. McArthur | Zendy; Melvyn Smith | Zendy; Susan Morgello | Zendy; Letty Mintz | Zendy; Will Toperoff | Zendy; Christina M. Marra | Zendy; Timothy A. Jones | Zendy; Eleanor Head | Zendy; M. Al-Lozi | Zendy; Mahlet Belachew | Zendy

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Efavirenz concentrations in CSF exceed IC50 for wild-type HIV

Author(s) -

Brookie M. Best,

P.P. Koopmans,

Scott Letendre,

Edmund V. Capparelli,

Steven S. Rossi,

David B. Clifford,

Ann C. Collier,

Benjamin B. Gelman,

Gilbert Mbeo,

J. Allen McCutchan,

David M. Simpson,

Richard Haubrich,

Ronald J. Ellis,

Igor Grant,

Thomas D. Marcotte,

Donald Franklin,

Thomas S. Alexander,

Robert K. Heaton,

J. Hampton Atkinson,

Steven Paul Woods,

M. Dawson,

Jacqueline Wong,

Christine FennemaNotestine,

Matthew Taylor,

Rebecca J. Theilmann,

Anthony Gamst,

Clint Cushman,

Ian Abramson,

Florin Vaida,

R. Jaeger,

Justin C. McArthur,

Melvyn Smith,

Susan Morgello,

Letty Mintz,

Will Toperoff,

Christina M. Marra,

Timothy A. Jones,

Eleanor Head,

M. Al-Lozi,

Mahlet Belachew

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq434

Subject(s) - efavirenz , interquartile range , medicine , pharmacokinetics , viral load , pharmacology , gastroenterology , ic50 , human immunodeficiency virus (hiv) , virology , antiretroviral therapy , chemistry , in vitro , biochemistry

HIV-associated neurocognitive disorders remain common despite use of potent antiretroviral therapy (ART). Ongoing viral replication due to poor distribution of antivirals into the CNS may increase risk for HIV-associated neurocognitive disorders. This study's objective was to determine penetration of a commonly prescribed antiretroviral drug, efavirenz, into CSF.

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