Plasma protein binding may reduce antimicrobial activity by preventing intra-bacterial uptake of antibiotics, for example clindamycin | Zendy

Angela Burian | Zendy; Christoph Wagner | Zendy; Johann Stanek | Zendy; Mohammad Manafi | Zendy; Michaela Böhmdorfer | Zendy; Walter Jäger | Zendy; Markus Zeitlinger | Zendy

Open Access

Plasma protein binding may reduce antimicrobial activity by preventing intra-bacterial uptake of antibiotics, for example clindamycin

Author(s) -

Angela Burian,

Christoph Wagner,

Johann Stanek,

Mohammad Manafi,

Michaela Böhmdorfer,

Walter Jäger,

Markus Zeitlinger

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq400

Subject(s) - antimicrobial , clindamycin , antibiotics , microbiology and biotechnology , bacterial growth , bacteria , chemistry , biology , genetics

although plasma protein binding (PPB) is accepted to be an essential factor in reducing antimicrobial activity, little is known about the underlying mechanisms. One possibility includes impaired penetration of an antimicrobial into bacterial cells in the presence of PPB. As a prerequisite for testing this hypothesis an optimized medium displaying high protein binding without impairing bacterial growth had to be identified for our model compound clindamycin.

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