Contribution of ROB-1 and PBP3 mutations to the resistance phenotype of a β-lactamase-positive amoxicillin/clavulanic acid-resistant Haemophilus influenzae carrying plasmid pB1000 in Italy | Zendy

Álvaro San Millán | Zendy; Maria Giufrè | Zendy; José Antonio Escudero | Zendy; Laura Hidalgo | Zendy; Belén GutiérrezGutiérrez | Zendy; Marina Cerquetti | Zendy; Bruno GonzálezZorn | Zendy

Open Access

Contribution of ROB-1 and PBP3 mutations to the resistance phenotype of a β-lactamase-positive amoxicillin/clavulanic acid-resistant Haemophilus influenzae carrying plasmid pB1000 in Italy

Author(s) -

Álvaro San Millán,

Maria Giufrè,

José Antonio Escudero,

Laura Hidalgo,

Belén GutiérrezGutiérrez,

Marina Cerquetti,

Bruno GonzálezZorn

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq392

Subject(s) - haemophilus influenzae , microbiology and biotechnology , pasteurella multocida , penicillin binding proteins , amoxicillin , clavulanic acid , pasteurellaceae , plasmid , haemophilus , cephalosporin , penicillin , phenotype , biology , virology , bacteria , antibiotics , gene , genetics

plasmid pB1000 bearing bla(ROB-1) is responsible for high-level β-lactam resistance in Haemophilus influenzae as well as in Pasteurella multocida and Haemophilus parasuis isolates from Spain. Here, we explore the presence of ROB-1 in Italy and investigate the relative contribution of penicillin-binding protein 3 (PBP3) mutations and ROB-1 to the β-lactam resistance phenotype in H. influenzae.

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