In vitro activity of cethromycin against Burkholderia pseudomallei and investigation of mechanism of resistance | Zendy

Takehiko Mima | Zendy; Herbert P. Schweizer | Zendy; Zhenghu Xu | Zendy

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In vitro activity of cethromycin against Burkholderia pseudomallei and investigation of mechanism of resistance

Author(s) -

Takehiko Mima,

Herbert P. Schweizer,

Zhenghu Xu

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq391

Subject(s) - efflux , burkholderia pseudomallei , microbiology and biotechnology , broth microdilution , biology , ketolide , in vitro , bacteria , minimum inhibitory concentration , antibiotics , antibacterial agent , biochemistry , genetics

most Burkholderia pseudomallei strains are intrinsically resistant to macrolides, mainly due to AmrAB-OprA- and/or BpeAB-OprB-mediated efflux. We assessed the in vitro anti-B. pseudomallei efficacy of cethromycin, a novel ketolide with broad-spectrum activity against Gram-negative and Gram-positive pathogens.

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