Open AccessAntibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance
Author(s) -
Nadine-C. Emrich,
Anke Heisig,
Will Stubbings,
Harald Labischinski,
Peter Heisig
Publication year - 2010
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkq375
Subject(s) - escherichia coli , microbiology and biotechnology , enterobacteriaceae , antibacterial activity , biology , antibacterial agent , bacteria , chemistry , antibiotics , biochemistry , genetics , gene
Finafloxacin is an investigational fluoroquinolone exhibiting broad-spectrum activity that is enhanced under slightly acidic conditions (pH 5.0-6.5). The impact of individual and combinations of chromosomal mutations (gyrA, parC and marR) and the plasmid-mediated fluoroquinolone resistance mechanisms QepA1, QnrA1, QnrB1, QnrS1 and AAC(6')-Ib-cr were investigated.