Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance | Zendy

Nadine-C. Emrich | Zendy; Anke Heisig | Zendy; Will Stubbings | Zendy; Harald Labischinski | Zendy; Peter Heisig | Zendy

Open Access

Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance

Author(s) -

Nadine-C. Emrich,

Anke Heisig,

Will Stubbings,

Harald Labischinski,

Peter Heisig

Publication year - 2010

Publication title -

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq375

Subject(s) - escherichia coli , microbiology and biotechnology , enterobacteriaceae , antibacterial activity , biology , antibacterial agent , bacteria , chemistry , antibiotics , biochemistry , genetics , gene

Finafloxacin is an investigational fluoroquinolone exhibiting broad-spectrum activity that is enhanced under slightly acidic conditions (pH 5.0-6.5). The impact of individual and combinations of chromosomal mutations (gyrA, parC and marR) and the plasmid-mediated fluoroquinolone resistance mechanisms QepA1, QnrA1, QnrB1, QnrS1 and AAC(6')-Ib-cr were investigated.

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