Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis | Zendy

Jurriaan E.M. de Steenwinkel | Zendy; Gerjo J. de Knegt | Zendy; M. T. ten Kate | Zendy; Alex van Belkum | Zendy; Henri A. Verbrugh | Zendy; Kristin Kremer | Zendy; Dick van Soolingen | Zendy; Irma A. J. M. BakkerWoudenberg | Zendy

Open Access

Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis

Author(s) -

Jurriaan E.M. de Steenwinkel,

Gerjo J. de Knegt,

M. T. ten Kate,

Alex van Belkum,

Henri A. Verbrugh,

Kristin Kremer,

Dick van Soolingen,

Irma A. J. M. BakkerWoudenberg

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq374

Subject(s) - mycobacterium tuberculosis , tuberculosis , drug resistance , microbiology and biotechnology , extensively drug resistant tuberculosis , medicine , immunology , pharmacodynamics , mycobacterium , biology , virology , pharmacology , pharmacokinetics , pathology

The pharmacodynamics of tuberculosis (TB) treatment should be further explored, to prevent emergence of resistance, treatment failure and relapse of infection. The diagnostic drug susceptibility tests guiding TB therapy investigate metabolically active Mycobacterium tuberculosis (Mtb) isolates under static conditions and as such are not informative with respect to the time-kill kinetics of anti-TB drugs and the emergence of resistance in metabolically lowly active or even dormant mycobacterial cells.

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