Phenotypic and genetic characterization of macrolide resistance in Francisella tularensis subsp. holarctica biovar I | Zendy

Brieuc Gestin | Zendy; Eric Valade | Zendy; François Thibault | Zendy; Dominik T. Schneider | Zendy; Max Maurin | Zendy

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Phenotypic and genetic characterization of macrolide resistance in Francisella tularensis subsp. holarctica biovar I

Author(s) -

Brieuc Gestin,

Eric Valade,

François Thibault,

Dominik T. Schneider,

Max Maurin

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq315

Subject(s) - biovar , biology , 23s ribosomal rna , microbiology and biotechnology , erythromycin , efflux , mutant , francisella tularensis , gene , genetics , antibiotics , virulence , ribosome , rna

Francisella tularensis subsp. holarctica strains are classified as biovars I and II, which are susceptible and naturally resistant to the macrolide erythromycin, respectively. The present study was aimed at both selecting biovar I strains with increased levels of erythromycin resistance and characterizing the underlying genetic mechanisms.

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