Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis | Zendy

Juan Guzman | Zendy; Antima Gupta | Zendy; Dimitrios Evangelopoulos | Zendy; Chandrakala Basavannacharya | Zendy; Ludy C. Pabón | Zendy; Erika Plazas | Zendy; Diego Ricardo Muñoz-Cendales | Zendy; Wilman A. Delgado | Zendy; Luís Enríque Cuca Suárez | Zendy; Wellman Ribón | Zendy; Simon Gibbons | Zendy; Sanjib Bhakta | Zendy

Open Access

Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis

Author(s) -

Juan Guzman,

Antima Gupta,

Dimitrios Evangelopoulos,

Chandrakala Basavannacharya,

Ludy C. Pabón,

Erika Plazas,

Diego Ricardo Muñoz-Cendales,

Wilman A. Delgado,

Luís Enríque Cuca Suárez,

Wellman Ribón,

Simon Gibbons,

Sanjib Bhakta

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq313

Subject(s) - mycobacterium bovis , mycobacterium tuberculosis , growth inhibition , microbiology and biotechnology , alkaloid , aporphine , biology , dna ligase , tuberculosis , mycobacterium , biochemistry , chemistry , bacteria , enzyme , cell growth , stereochemistry , medicine , genetics , pathology

New anti-mycobacterial entities with novel mechanisms of action are clinically needed for treating resistant forms of tuberculosis. The purpose of this study was to evaluate anti-tubercular activity and selectivity of seven recently isolated natural products from Colombian plants.

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