Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae | Zendy

Farid El Garch | Zendy; Ann Lismond | Zendy; Laura J. V. Piddock | Zendy; Patrice Courvalin | Zendy; Paul M. Tulkens | Zendy; Françoise Van Bambeke | Zendy

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Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae

Author(s) -

Farid El Garch,

Ann Lismond,

Laura J. V. Piddock,

Patrice Courvalin,

Paul M. Tulkens,

Françoise Van Bambeke

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq287

Subject(s) - efflux , major facilitator superfamily , microbiology and biotechnology , streptococcus pneumoniae , streptococcaceae , biology , atp binding cassette transporter , klebsiella pneumoniae , superfamily , bacteria , gene , transporter , genetics , antibiotics , escherichia coli

Active efflux is a common mechanism of resistance to fluoroquinolones in Streptococcus pneumoniae. Two efflux systems have been described so far in this species: PmrA, a member of the major facilitator superfamily; and the two ABC transporters PatA and PatB. We studied the inducibility of expression of pmrA, patA and patB by using subinhibitory concentrations of fluoroquinolones.

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