Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus -lactamase-producing Enterobacteriaceae | Zendy

D. M. Livermore | Zendy; Shazad Mushtaq | Zendy; Y Ge | Zendy

Open Access

Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus -lactamase-producing Enterobacteriaceae

Author(s) -

D. M. Livermore,

Shazad Mushtaq,

Y Ge

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq248

Subject(s) - cephalosporin , ceftazidime , enterobacteriaceae , tazobactam , piperacillin/tazobactam , microbiology and biotechnology , carbapenem , cefepime , medicine , antibiotics , biology , piperacillin , escherichia coli , imipenem , bacteria , pseudomonas aeruginosa , antibiotic resistance , genetics , gene , biochemistry

The developmental oxyimino-cephalosporin CXA-101 (FR264205) is notable for having greater antipseudomonal activity than ceftazidime. It is active against Enterobacteriaceae too, but is compromised by extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases. We investigated the tazobactam concentrations needed to potentiate this cephalosporin against strains with these mechanisms.

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